Letrozole is an oral fertility enhancing medication for patients with ovulatory problems such as failure to ovulate or inconsistent ovulation. Some patients with ovulation difficulty have other medical conditions that require specific therapy such a Synthroid for hypothyroidism.
Letrozole is offered to patients who have no known medical condition hindering ovulation and to patients whose medical treatment by itself fails to stimulate ovulation. Some terms for ovulation dysfunction are: PCOS polycystic ovary syndrome , anovulation, irregular ovulation, luteal phase deficiency, and progesterone deficiency. History and physical in the office 2.
Semen analysis 3. Progestin challenge for those who are not having any periods : A progesterone-type hormone is prescribed to attempt to induce a period. Call us if you do not have a period beginning days after you finish the prescription. Measure content performance. Develop and improve products. List of Partners vendors. Femara letrozole is an oral medication used to stimulate ovulation in women with polycystic ovary syndrome PCOS and unexplained infertility.
Food and Drug Administration for use as a breast cancer drug, it has been used off-label by fertility doctors since because it has fewer side effects than Clomid clomiphene and a lower risk of multiple pregnancies. Clomid is the current first-line choice for treating infertility in women with PCOS. Recent research, however, has suggested that Femara may offer significantly higher rates of pregnancy within this population of women. Femara is also commonly used in cases of Clomid resistance when Clomid is unable to stimulate ovulation over at least three treatment cycles and despite increasing dosages.
Femara is offered in 2. Based on when your period begins, your doctor will advise you when to start treatment. Treatment will be taken over five consecutive days. Some fertility experts recommend taking the pills on days 3, 4, 5, 6 and 7 of your cycle. Others endorse days 5, 6, 7, 8, and 9. While there remains debate on which option is truly best, current research seems to suggest that success rates are more-or-less the same.
Based on when treatment began, you can anticipate when you would need to start having sex:. To better pinpoint the time of ovulation, you can use an ovulation predictor kit.
You would start testing once you've completed treatment and test daily until you receive a positive result indicating that you are nearing ovulation.
This is the signal to begin having sex. Femara can also be used for intrauterine insemination IUI treatment. Clomid is sometimes prescribed alongside Femara and taken together on the same days.
Letrozole works by reducing estrogen levels in order to stimulate ovulation. Those most commonly seen with Femara use include:. If you experience blurred vision or any symptoms that seem especially severe, contact your doctor immediately.
Once the follicles have grown to 18mm or larger, you will be given an injection of hCG to trigger ovulation and the IUI will be scheduled the following day. An ultrasound is recommended during your first treatment cycle to check the effectiveness of the medications. If you are timing the IUI by ovulation predictor kit, you should start checking your urine early in the morning with the kit on Cycle Day Most women will have a positive test around Cycle Day 13 or Once the test is positive, call the clinic to schedule the IUI.
Semen collection is scheduled in the clinic the following day and the IUI is usually performed approximately 1 — 2 hours later. If you have a positive surge on a weekend you will need to leave a message early in the morning no later than am so that we may call you back to schedule your IUI for the following day.
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